Enhancement of renal concentrating ability in the rat by acetamide and methylurea

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Abstract
The effect of acute administration of methylurea, acetamide, and urea on the renal concentrating ability of vasopressin-infused rats was studied. In each experiment mannitol was infused to obtain an index of basal concentrating ability; then methylurea, acetamide, or urea was infused in amounts designed to maintain the previous solute excretion rate. Their infusion resulted in an increase in urine osmolality, U/P osmolality ratio, and TcH2O. The increase in urine osmolality was always exceeded by a rise in the concentration of methylurea, acetamide, and urea in the tissue water of the renal papilla, and this was in turn exceeded by the rise in the concentration of these compounds in the urine. Each compound was accumulated in the kidney along a concentration gradient which increased from cortex to tip of the papilla. Enhancement of renal concentrating ability by methylurea and acetamide is due to the accumulation of each compound in the interstitial fluid of the renal papilla in high concentration secondary to its passive reabsorption from the collecting ducts.

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