In-vitro susceptibility of thirty strains of Haemophilus ducreyi to several antibiotics including six cephalosporins

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Abstract
We have studied the in-vitro susceptibility of 30 strains of Haemophilus ducreyi to 22 antibacterial agents. Twenty-seven strains produced a η-lactamase that had an isoelectric point similar to the isoelectric point of the TEM 1 type β-lactamase produced by pSF 2124. Except for cefamandole, the 30 strains had similar susceptibilities to the different cephalosporins, cefotaxime being the most active compound. Twenty-two isolates were resistant to tetracycline and doxycycline; minimal inhibitory concentration (MIC) of minocycline was 4 mg/1 for all the strains. One isolate was resistant to chloramphenicol (MIC= 16mg/l). All strains were relatively resistant to colistin and nalidixic acid, and susceptible to streptomycin, kanamycin, gentamicin, erythromycin, rifampicin and vancomycin.

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