Attenuation of stereotyped behaviour by sex steroids
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 57 (2) , 211-214
- https://doi.org/10.1007/bf00426890
Abstract
Effects of sex steroids, testosterone, progesterone, and estradiol on PEA-induced stereotyped behaviour (SB) has been studied in normal, castrated, and ovariectomised mice. Effects of sex steroids on amphetamine-induced stereotypy and hyperactivity are also described. In castrated and ovariectomised mice B-phenylethylamine (PEA) increased SB. Pretreatment with sex steroids attenuated PEA-induced stereotypy in normal, castrated, and ovarietomised mice. Sex steroid pretreatment significantly inhibited PEA- and amphetamine-induced SB, but failed to alter increased motor activity due to amphetamine or PEA. The possible effect of sex steroids on SB through changes in central neurotransmitters are discussed.Keywords
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