Prometaphase chromosome analysis as a routine diagnostic technique
- 1 May 1986
- journal article
- research article
- Published by Wiley in Clinical Genetics
- Vol. 29 (5) , 378-383
- https://doi.org/10.1111/j.1399-0004.1986.tb00508.x
Abstract
The use of techniques for the production of prometaphase chromosomes leading to increased resolution of banding patterns has resulted in problems as well as advantages in their routine use. A simple technique utilising the folate antagonist methotrexate has been in use in this regional diagnostic cytogenetics centre for three years, and a number of chromosome abnormalities have been detected in cases previously reported as normal following G banding studies. With reference to this, the routine analysis of prometaphase-type chromosomes is discussed and assessed.Keywords
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