Vaccination with Attenuated Simian Immunodeficiency Virus by DNA Inoculation
Open Access
- 1 December 2001
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 75 (23) , 11930-11934
- https://doi.org/10.1128/jvi.75.23.11930-11934.2001
Abstract
Delivering attenuated lentivirus vaccines as proviral DNA would be simple and inexpensive. Inoculation of macaques with wild-type simian immunodeficiency virus strain mac239 (SIV mac239 ) DNA or SIV mac239 DNA containing a single deletion in the 3′ nef -long terminal repeat overlap region ( nef /LTR) led to sustained SIV infections and AIDS. Injection of SIV mac239 DNA containing identical deletions in both the 5′ LTR and 3′ nef /LTR resulted in attenuated SIV infections and substantial protection against subsequent mucosal SIV mac251 challenge.Keywords
This publication has 19 references indexed in Scilit:
- Live Attenuated HIV Vaccines: A Proposal for Further Research and DevelopmentAIDS Research and Human Retroviruses, 2000
- Induction of HIV‐1‐specific T‐helper responses and type 1 cytokine secretion following therapeutic vaccination of macaques with a recombinant fowlpoxvirus co‐expressing interferon‐gammaJournal of Medical Primatology, 2000
- Immunologic and Virologic Status after 14 to 18 Years of Infection with an Attenuated Strain of HIV-1 — A Report from the Sydney Blood Bank CohortNew England Journal of Medicine, 1999
- Viremia and AIDS in Rhesus Macaques after Intramuscular Inoculation of Plasmid DNA Encoding Full-Length SIVmac239AIDS Research and Human Retroviruses, 1999
- Genomic Structure of an Attenuated Quasi Species of HIV-1 from a Blood Transfusion Donor and RecipientsScience, 1995
- Pathogenicity of Live, Attenuated SIV After Mucosal Infection of Neonatal MacaquesScience, 1995
- Construction andIn VitroProperties of SIVmacMutants with Deletions in "Nonessential" GenesAIDS Research and Human Retroviruses, 1994
- Protective Effects of a Live Attenuated SIV Vaccine with a Deletion in the nef GeneScience, 1992
- Importance of the nef gene for maintenance of high virus loads and for development of AIDSCell, 1991
- Risks of handling HIVNature, 1991