Assessment of bleomycin, adriamycin and mitomycin‐C in the treatment of recurrent cervical cancer

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Abstract
Twenty women with recurrent squamous cell carcinoma of the cervix were treated with bleomycin followed by adriamycin and mitomycin-C. Treatment was repeated every 28 days. In 18 patients who could be assessed there was 1 complete response and 5 partial responses (response rate 33%). Two partial responses were seen in 13 lesions arising from previously irradiated sites of disease (response rate 23%). Three complete responses and 3 partial responses were observed in 10 lesions arising from non-previously irradiated sites of disease (response rate 60%). In all responding cycle of treatment. Toxicity was predictable and manageable. Chemotherapy evidently may be used as a cytoreductive procedure before radical local treatment.