Sickle cell anemia: Erythrokinetics, blood volumes, and a study of possible determinants of severity

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Abstract
Erythrokinetics, blood volumes and variables which influence Hb function in a group of adults with sickle cell anemia of varying degrees of clinical severity were examined. No correlations of any single measurement with the clinical course were found; however; the patient sample was small and the data suggested areas for further study. An expansion of plasma volume was noted in all patients. This made it difficult to predict red cell mass from the Hb level, which consistently underestimated its magnitude. The red cell production index and Fe turnover values indicated that there is often a suboptimal erythropoietic response to anemia in sickle cell disease.