β2‐Microglobulin in Chronic Lymphocytic Leukaemia

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Abstract
The serum level of β2‐microglobulin (S‐β2m), a cell membrane protein associated with HLA‐antigens, was quantitated in a series of 23 consecutive patients with chronic lymphocytic leukaemia (CLL). Markedly elevated values of S‐β2m (> 4.5 mg/l) were found in 10 patients, while only 3 patients had normal values (< 3.0 mg/l). High serum values correlated with a large tumour mass, as estimated by Rai's clinical staging and by the total peripheral lymphocyte count. Blood lymphocyte proliferative activity, which has been suggested as reflecting disease activity in CLL, was measured by 3H‐thymidine uptake in cells in vitro. The 3H‐thymidine uptake was high in 3 patients all of whom were among the 5 patients with the highest S‐β2m‐values. S‐β2m‐determinations seem to be of definite interest in the study of patients with CLL although long term studies will be necessary for evaluation of the practical clinical value.

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