ALK‐ATIC fusion in urinary bladder inflammatory myofibroblastic tumor
- 6 August 2003
- journal article
- case report
- Published by Wiley in Genes, Chromosomes and Cancer
- Vol. 38 (2) , 187-190
- https://doi.org/10.1002/gcc.10267
Abstract
In this report, we describe an inflammatory myofibroblastic tumor (IMT) of the urinary bladder in a 46‐year‐old man. Tumor cells presented striking cytoplasmatic ALK immunopositivity. Cytogenetic and FISH analysis, by use of a multicolor chromosome 2 banding probe, revealed a 46,XY,der(2)(2pter→2p23:2q35→2q37:2p11→2q35:2p23→2p11:2q37→2qter) karyotype. Subsequent FISH and RT‐PCR analysis confirmed the ALK‐ATIC chimeric fusion in tumor cells. This is the first evidence of a variant rearrangement involving the ATIC gene in IMT and the first cytogenetic description of an IMT originating from the urinary bladder.Keywords
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