Age-Related Responsiveness of the Rat to Drugs Affecting the Central Nervous System
- 1 December 1974
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 147 (3) , 593-595
- https://doi.org/10.3181/00379727-147-38395
Abstract
Responses to sodium hexobarbital, chlorpromazine HCl, morphine SO4 and d-amphetamine SO4 were evaluated in 2.5-3 mo. old and 9-10 mo. old male rats. The control responses which were measured, body temperature, spontaneous motor activity and pain thresholds were not different in the 2 age groups studied. When the animals were challenged with the drugs a significantly higher responsiveness to the drugs occurred in the older animals.This publication has 2 references indexed in Scilit:
- Determination of nanogram quantities of chlorpromazine and some of its metabolites in plasma by using gas-liquid chromatography with an electron capture detectorAnalytical Chemistry, 1968
- Estimation of Brain Sensitivity to Hexobarbitone (Enhexymal NFN) in Rats by an EEG ThresholdActa Pharmacologica et Toxicologica, 1966