Influence of Hypothalamic Fragments and Extracts on Lactogen Production in vitro

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Abstract
Summary Anterior pituitaries from estrous cyclic and lactating, hooded Norway rats were cultured in synthetic medium (Mixture 199) with hypothalamic extracts or frag ments for a period of 3 days at a 300 cc/min gas flow of 95% Oz-5% COe. In 5 experiments, lactogen production was decreased an average 22.3% by the addition of hypothala mus. Hypothalamic extracts and hypothalam ic fragments from either estrous cyclic or lactating animals were capable of inhibiting pituitary lactogen production in vitro. Addition of cerebral cortical extracts to the culture system did not significantly alter lactogen production. Lactogen content of cultured pituitary tissue and AP viability ratings of hypothalamic groups did not differ significantly from those of controls.

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