SULPHAMETHOXAZOLE‐TRIMETHOPRIM IN INFANCY

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Abstract
Two infants with coliform infections were treated with a combination of sulphamethoxazole and trimethoprim (“Bactrim”). The first had a urinary tract infection which failed to respond to sulphamethoxazole, in a dosage of 20 mg/kg/day, and trimethoprim, 4 mg/kg/day, given for seven days. This baby was submitted to surgery to correct gross bilateral ureteric reflux. He subsequently developed septicæmia and pancytopenia and died. The second patient had meningitis which had failed to respond to conventional antibiotic therapy. A dose of “Bactrim”, nearly double that given to the first patient, was given for nine weeks with a satisfactory outcome and no significant toxicity. Sulphamethoxazole, 40 to 50 mg/kg/day, and trimethoprim, 8 to 10 mg/kg/day, is the dosage now being used in continuing evaluation.