Bacteriophage Clearance in the Oyster ( Crassostrea virginica )

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Abstract
Since relatively few quantitative immunological studies had been conducted with invertebrates, this study was designed to learn more about the immune potential of the oyster, a molluscan representative. Experiments measured the primary and secondary clearance rates of T2 coliphage in the oyster. The fate of phage injected intracardially or intramuscularly was traced by measuring serum and tissue fluid plaque-forming unit levels at various times postinjection. Phage-neutralizing activity was also measured. Although circulating T2-neutralizing antibody was not induced in the oyster, secondary injections of T2 were cleared more rapidly than primary injections. The difference in clearance rates between primary and secondary groups was not as pronounced in the oyster as in the lemon shark, an animal capable of producing high levels of serum antibody to T2.

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