Role of Enzymatic Adaptation in Production of Experimental Alkaptonuria.
- 1 November 1957
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 96 (2) , 501-505
- https://doi.org/10.3181/00379727-96-23520
Abstract
Experimental alkaptonuria in rats maintained on a high tyrosine diet is associated with an increased ratio of the activity of the tyrosine transaminase to the activity of the homogentisate oxidase in the liver. The alkaptonuria is the result of an adaptive increase in the relative rate of homogentisate formation, in contrast to the relative decrease in the rate of homogentisate degradation believed to be responsible for hereditary alkaptonuria in man.Keywords
This publication has 5 references indexed in Scilit:
- p-HYDROXYPHENYLPYRUVATE OXIDASE OF LIVERJournal of Biological Chemistry, 1957
- ENZYMIC CATALYSIS OF THE KETO-ENOL TAUTOMERIZATION OF PHENYLPYRUVIC ACIDSJournal of Biological Chemistry, 1957
- HOMOGENTISATE OXIDASE OF LIVERJournal of Biological Chemistry, 1955
- Studies on alcaptonuriaBiochemical Journal, 1947
- Studies on alcaptonuriaBiochemical Journal, 1947