A Novel Tea-Bag Methodology for Enzymatic Resolutions of α-Amino Acid Derivatives in Reverse Micellar Media
- 1 August 1994
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 24 (15) , 2109-2118
- https://doi.org/10.1080/00397919408010223
Abstract
A novel tea bag methodology for resolution of methyl esters of N-acetyl-α-amino acids in reverse micellar medium of bis (2-ethylhexyl) sulfosuccinate sodium salt (AOT) in isooctane-chloroform using immobilized enzymes or microbial cells is presented. The methodology effectively solves the problems of substrate solubility, product separation and surfactant recycling and provides products in high yields (80 to 90%) and excellent optical purities (% ee 97 to >99%).Keywords
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