Development of Cellular Dependence on Infective Organisms: Micrurgical Studies in Amoebas

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Abstract
Nuclei and cytoplasm were transferred between a normal strain anda variant strain of Amoeba discoides heavily infected with bacteria. After 5 years of infection, the infective bacteria that were initially harmful to the host cells became harmless, and the nucleus of the host cell became dependent on the infective organisms for its normal functions.