No Linkage between HLA and Congenital Adrenal Hyperplasia Due to 11-β-Hydroxylase Deficiency

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Abstract
To the Editor: The various forms of congenital adrenal hyperplasia are caused by different enzymatic deficiencies, each responsible for a given step in the biosynthesis of cortisol or aldosterone (or both). The most frequent forms of this disorder result from deficiencies of the 21-hydroxylase and 11-hydroxylase enzymes.1 These enzymes function sequentially in steroid biosynthesis and therefore may be genetically linked, similar perhaps to the lactose system in Escherichia coli.2 Since close genetic linkage between congenital adrenal hyperplasia, 21-hydroxylase deficiency and the B locus of the HLA system has recently been shown,3 4 5 it was of interest to determine if the . . .