SPECIFICITY OF ISONIAZID DROP TEST FOR CONTROL OF DOMICILIARY TREATMENT OF TUBERCULOSIS

  • 1 January 1964
    • journal article
    • research article
    • Vol. 90  (11) , 695-+
Abstract
A method for determining N-acetyl-isoniazid in urine was specific in urine specimens from patients in a sanatorium. The patients in the Tuberculosis Division were receiving isoniazid and other antituberculosis drugs alone or in combination. The patients in the Mental Health Division and in the general hospital were receiving a wide variety of other drugs. After a single dose of 300 mg of isoniazid, N-acetyl-isoniazid could be detected in urines of 36 patients for at least 12 hrs. In 3 24-hr. urine specimens trace amounts could still be demonstrated.

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