Total Cardiac By-pass Utilizing Continuous Perfusion from Reservoir of Oxygenated Blood.

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Abstract
This method utilizes the continuous perfusion of the recipient''s arterial system from a reservoir of oxygenated blood. An equivalant quantity of venous blood is removed from the recipient s superior and inferior cavae. A pump is utilized to control this exchange of blood between the recepient and the arterial and venous reservoirs. Arterial blood for the reservoir was obtained beforehand from a donor animal used as an oxygenator independent of the perfusion system. This was done by collecting arterial blood from the donor s femoral artery into a heparin-glucose solution while stored venous blood was infused into his femoral vein at an equal rate. Ordinarily 2000-3500 cc of arterial blood was collected from a single donor dog in this fashion. Optimum dose of heparin to prevent clotting in the arterial blood collected for this purpose was 25-32 mg/l of blood. Hematologic and metabolic changes occurring in animals whose heart and lungs were totally bypassed for 20 minutes are recorded.