A SIMPLE STEREOSELECTIVE SYNTHESIS OF (lR,3R,5S)-1,3-DIMETHYL-2,9-DIOXABICYCLO[3,3,1]NONANE USING REGIOSELECTIVE RING-OPENING OF (R)-β-METHYL-β-PROPIOLACTONE
- 5 September 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 12 (9) , 1391-1392
- https://doi.org/10.1246/cl.1983.1391
Abstract
A facile stereoselective synthesis of (1R,3R,5S)-1,3-dimethyl-2,9-dioxabicyclo[3.3.1]nonane was achieved from (R)-2-hydroxy-7-octen-4-one, which was easily prepared by the copper-catalyzed reaction of (R)-β-methyl-β-propiolactone with vinylmagnesium bromide.Keywords
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