The Effect of Tocopheryl Esters on Influenza Virus

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Abstract
Because tocopi eryl esters inhibit the activity of hyaluronidase, and there are some resemblances between activities and substrates of hyaluroi dase and the influenza virus enzyme, the effect of tocopheryl esters on influenza virus was investigated. The enzymatic activity of the virus was followed by measuring the destruction by the virus of the hemagglutination inhibiting properties of ovomucin and it was found that alpha-tocopheryl phosphate and alpha-tocopheryl succinate interfered with this activity while a mixture of delta and gamma-tocopheryl phosphates did not. It was also found that the alpha-tocopheryls protected 10- to 12-day-old chick embryos against infection by small doses of influenza virus and the delta, gamma-tocopheryls did not. This is the same relative effectiveness found by others against hyaluronidase.