Effects of single dose proton irradiation of normal skin and Vx2 carcinoma in rabbit ears

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Abstract
Normal rabbit skin and subcutaneously implanted Vx2 carcinoma were irradiated with protons from a synchrocyclotron, the Bragg peak region of the proton beam being used. The effect was compared with that of 220kV X-rays. Qualitatively the regressive changes were the same. Semi-quantitative grading of the radiation-induced gross changes of the skin showed that protons produced less damage than approximately equivalent doses of X-rays. Semi-quantitative grading was also applied to the microscopic regressive changes evoked in the Vx2 carcinoma cells during the first week after irradiation. The proton beam had approximately the same ability as conventional X-rays to produce early regressive changes at roughly corresponding doses. The findings give biological support to the idea that the proton beam, with its advantageous physical properties may be used to treat malignant tumors.

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