Regulation of the Expression of Inducible Nitric Oxide Synthase
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- 7 January 2003
- journal article
- review article
- Published by Walter de Gruyter GmbH in Biological Chemistry
- Vol. 384 (10-11) , 1343-64
- https://doi.org/10.1515/bc.2003.152
Abstract
Nitric oxide (NO), generated by the inducible isoform of nitric oxide synthase (iNOS), has been described to have beneficial microbicidal, antiviral, antiparasital, immunomodulatory, and antitumoral effects. However, aberrant iNOS induction at the wrong place or at the wrong time has detrimental consequences and seems to be involved in the pathophysiology of several human diseases. iNOS is primarily regulated at the expression level by transcriptional and post-transcriptional mechanisms. iNOS expression can be induced in many cell types with suitable agents such as bacterial lipopolysaccharides (LPS), cytokines, and other compounds. Pathways resulting in the induction of iNOS expression may vary in different cells or different species. Activation of the transcription factors NF-kappaB and STAT-1alpha, and thereby activation of the iNOS promoter, seems to be an essential step for iNOS induction in most cells. However, at least in the human system, also post-transcriptional mechanism are critically involved in the regulation of iNOS expression. The induction of iNOS can be inhibited by a wide variety of immunomodulatory compounds acting at the transcriptional levels and/or post-transcriptionally.Keywords
This publication has 223 references indexed in Scilit:
- Rho protein-mediated changes in the structure of the actin cytoskeleton regulate human inducible NO synthase gene expressionExperimental Cell Research, 2003
- Group IIA secretory phospholipase A2 stimulates inducible nitric oxide synthase expression via ERK and NF-κB in macrophagesEuropean Journal of Immunology, 2001
- HuR and mRNA stabilityCellular and Molecular Life Sciences, 2001
- Retinoic Acid Inhibits Nitric Oxide Synthase-2 Expression through the Retinoic Acid Receptor-αBiochemical and Biophysical Research Communications, 2000
- Inhibition of Experimental Melanin Protein-induced Uveitis (EMIU) by Targeting Nitric Oxide via Phosphatidylcholine-specific Phospholipase CJournal of Autoimmunity, 1999
- Oxidative Stress Increases Hepatocyte iNOS Gene Transcription and Promoter ActivityBiochemical and Biophysical Research Communications, 1997
- Expression of Human Inducible Nitric Oxide Synthase Is Regulated by both Promoter and 3′-RegionsBiochemical and Biophysical Research Communications, 1997
- Transcriptional Regulation of the Human iNOS Gene in Vascular-Smooth-Muscle Cells and Macrophages: Evidence for Tissue SpecificityBiochemical and Biophysical Research Communications, 1996
- Regulation of Cytokine-inducible Nitric Oxide Synthase in Cardiac Myocytes and Microvascular Endothelial Cells: ROLE OF EXTRACELLULAR SIGNAL-REGULATED KINASES 1 AND 2 (ERK1/ERK2) AND STAT1αPublished by Elsevier ,1996
- Interleukin 1β-Induced Expression of Nitric Oxide Synthase in Rat Renal Mesangial Cells Is Suppressed by Cyclosporin ABiochemical and Biophysical Research Communications, 1995