Increased midbrain gray matter in Tourette's syndrome
- 25 January 2006
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 59 (2) , 381-385
- https://doi.org/10.1002/ana.20765
Abstract
Objective To investigate cerebral structure in Tourette's syndrome (TS). Methods Voxel‐based morphometry study of high‐resolution MRIs in 31 TS patients compared with 31 controls. Results Increased gray matter mainly in the left mesencephalon in 31 TS patients. Interpretation This result constitutes strong and direct evidence supporting Devinsky's hypothesis (Devinsky O. Neuroanatomy of Gilles de la Tourette's syndrome. Possible midbrain involvement. Arch Neurol 1983;40:508–514) according to which midbrain disturbances play an important pathogenic role in TS. Ann Neurol 2006;59:381–385Keywords
Funding Information
- Fondation Horlait-Dapsens
- Belgian American Educational Foundation
- Nato
- NIH
- National Institute of Neurological Disorders and Stroke
- “Fondation Léon Frédéricq”
This publication has 19 references indexed in Scilit:
- Basal Ganglia Volumes in Patients With Gilles de la Tourette SyndromeArchives of General Psychiatry, 2003
- Immediate and long term outcome after infrathalamic and thalamic lesioning for intractable Tourette's syndromeJournal of Neurology, Neurosurgery & Psychiatry, 2001
- Disappearance of motor tics after Wernicke's encephalopathy in a patient with Tourette's syndromeNeurology, 1997
- Three cases of symptom change in Tourette's syndrome and obsessive-compulsive disorder associated with paediatric cerebral malignancies.Journal of Neurology, Neurosurgery & Psychiatry, 1996
- Cerebral morphometric abnormalities in Tourette's syndromeNeurology, 1995
- Volumetric MRI changes in basal ganglia of children with Tourette's syndromeNeurology, 1993
- Reduced basal ganglia volumes in Tourette's syndrome using three‐dimensional reconstruction techniques from magnetic resonance imagesNeurology, 1993
- Controlled Study of Haloperidol, Pimozide, and Placebo for the Treatment of Gilles de la Tourette's SyndromeArchives of General Psychiatry, 1989
- A Case of Tourette's Syndrome with Midbrain InvolvementInternational Journal of Neuroscience, 1988
- Neuroanatomy of Gilles de la Tourette's Syndrome Possible Midbrain InvolvementArchives of Neurology, 1983