Influence of thyroid function on the blood clotting system

Publisher Website
Google Scholar
Abstract
The clotting system was investigated in seven adult patients with hyperthyroidism, three men and four women. The patients plasmas showed short cephalin times, and AHA (factor VIII) activities were definitely above normal levels. In a female patient with hypothyroidism and bleeding tendency, the bleeding time was prolonged, the plasma cephalin time definitely longer than normal, and plasma AHA activity abnormally low. The results of hemostatic tests were thus similar to those observed in cases with von Willebrand''s disease. After 1-thyroxin sodium treatment, however, the bleeding time, the plasma cephalin time and the AHA activity became normal, simultaneously with normalization of BMR and with disappearance of her myxedematous symptoms. Her bleeding tendency also disappeared after the start of thyroxin treatment. The results of the investigations indicate that blood AHA activity is markedly dependent on thyroid function, and is thus correlated with the tissue metabolic rate.

This publication has 11 references indexed in Scilit: