EFFECTS OF THE NEW CALCIUM-ANTAGONIST 2-NITRATOPROPYL-3-NITRATOPROPYL-2,6-DIMETHYL-4-(3-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE ON CEREBRAL-CIRCULATION IN DOGS

  • 1 November 1987
    • journal article
    • research article
    • Vol. 37-2  (11) , 1239-1243
Abstract
2-Nitratopropyl-3-nitratopropyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (CD-349), nimodipine and nicardipine (0.3-3 .mu.g/kg i.v.) increased vertebral blood flow (VBF) in the anesthetized dog, the effect of CD-349 being the strongest, and they also decreased blood pressure. All these drugs slightly increased femoral blood flow. CD-349, nimodipine and nicardipine (1-10 .mu.g/kg i.v.) increased cerebral tissue blood flow (CBF) in the anesthetized dog, CD-349 producing the most sustained and pronounced effect. CD-349 (3 .mu.g/kg i.v.) restored the decrease of CBF induced by the application of 0.5 ml of secrotonin (5-HT, 10-5 mol/l), KCl (30 mmol/l) and prostaglandin F2.alpha. (PGF2.alpha., 10-4 mol/l) to the surface of the cerebrum of the anaesthetized dog. In isolated canine basilar arteries, K-contraction was completely inhibited, but the relaxation of 5-HT- and PGF2.alpha.-contractions by these drugs was incomplete. CD-349 had a more potent effect than nicardipine and nimodipine on basilar arteries. These results indicate tht CD-349 is a potent cerebrovasodilator.