Benzomorphan-related compounds. Part 21. Synthesis of 7,8-benzomorphans via 2-aryl-4-piperidones
- 1 January 1986
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 8,p. 1533-1539
- https://doi.org/10.1039/p19860001533
Abstract
A new synthesis of 1,2,3,4,5,6-hexahydro-1,5-methano-2-benzazocines (7,8-benzomorphans) based on the acid-catalysed cyclization of 2-arylpiperidine-4-carboxylic acids is reported. The required carboxylic acids were prepared from 2-aryl-4-piperidones, by reaction with tosylmethyl isocyanide followed by hydrolysis of the resulting 4-cyanopiperidines.This publication has 9 references indexed in Scilit:
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