More on Rotavirus Vaccination and Intussusception

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Abstract
In the February 22 issue of the Journal, we reported a strong and temporal association between vaccination with rhesus–human reassortant rotavirus vaccine (RRV-TV) and intussusception, which we found by examining the rate of intussusception during predefined periods after vaccination.1 Excess cases of intussusception above the base-line rate were evident when the number of occurrences was averaged over the maximal available follow-up period, a mean of 3.7 months per infant (adjusted odds ratio for intussusception, 2.2; 95 percent confidence interval, 1.5 to 3.3). During days 3 to 7 after dose 1, the adjusted odds ratio was 37.2 (95 percent confidence interval, 12.6 to 110.1). We presented odds ratios for other periods up to 21 days after each dose, on the premise that the rate of intussusception returned to base-line levels after 21 days.