FIELD STUDIES WITH A NEW TICK-BORNE ENCEPHALITIS (TBE) VACCINE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 234  (1) , 141-144
Abstract
The vaccine used contained formalin-inactivated TBE virus that was grown in chick embryo cells and adsorbed to Alhydrogel. In a 1st study conducted in 1973, 81 volunteers were given s.c. 2 doses of vaccine 4 wk apart, and a 3rd dose 7-9 mo. later. After each vaccination the rates of seroconversion were assayed in the hemagglutination inhibition test. The values obtained were 76%, 96% and 98%, respectively. The geometric mean titers were 1:26, 1:36 and 1:44. The vaccine was well tolerated locally, and systematic reactions such as fever, headache and fatigue were only recorded after the 1st dose of vaccine. In 1974 and 1975, 30,000 persons were vaccinated in areas where the disease is endemic. Most of the vaccinees work in forests and are, therefore, at high risk of infection. Circumstantial evidence indicates that the vaccine is protective.

This publication has 0 references indexed in Scilit: