Long term experiment of perfluorochemicals using rabbits
- 1 January 1982
- journal article
- research article
- Published by Springer Nature in Virchows Archiv
- Vol. 398 (1) , 1-10
- https://doi.org/10.1007/bf00585608
Abstract
Morphological changes six months to two years after the administration of Perfluorochemicals (PFC) in rabbits injected with a large amount of PFC (67 mg/kg) have already been reported by Ohnishi and Kitazawa (1979, 1980, and 1981). In this paper, the authors report on the persistance of large numbers of foamy cells in the liver, spleen and lymph nodes and many in the kidneys, lung and bone marrow, up to two years after administration. Quantitative analysis of PFC in various organs showed that it was retained. The liver revealed progressive fibrosis surrounding the foamy cells in or around the Glisson's sheath.Keywords
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