LITHIUM INDUCES ABNORMAL CALCIUM-REGULATED PTH RELEASE IN DISPERSED BOVINE PARATHYROID CELLS1

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Abstract
The effects of lithium on calcium-regulated parathyroid hormone (PTH) release were assessed in collagenase- dispersed bovine parathyroid cells. Preincubation for 4 hours with LiCl caused a dose-dependent increase in the concentration of calcium required for half-maximal inhibition of imnunoreactive PTH release (the “setpoint” for calcium). A significant increase in “set-point” was observed following exposure to 1.25 mM lithium, a concentration within the therapeutic range for man. This effect required preincubation with LiCl, was not seen with NaCl or KC1, and persisted despite removal of extracellular lithium. This lithium-induced abnormality in calcium-regulated PTH secretion may be a useful model system for analyzing the analogous defect in secretory control in primary hyperparathyroidism.