Mice Lacking Interleukin-2 (IL-2)/IL-15 Receptor β Chain Are Susceptible to Infection with AvirulentSalmonella entericasubsp.entericaSerovar Choleraesuis but Mice Lacking IL-2 Are Resistant

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Abstract
Interleukin-2 (IL-2)/IL-15 receptor β (IL-15Rβ)−/−mice were susceptible to infection with avirulentSalmonella entericasubsp.entericaserovar Choleraesuis, whereas IL-2−/−mice were resistant. A natural killer cell response was not evident for both types of deficient mice. A Th1 response was detected in IL-2−/−but not in IL-2/IL-15Rβ−/−mice infected withSalmonella, suggesting that IL-2/IL-15Rβ signaling is important for the generation of protective Th1 cells.