X chromosome map at 75-kb STS resolution, revealing extremes of recombination and GC content.
Open Access
- 1 March 1997
- journal article
- Published by Cold Spring Harbor Laboratory in Genome Research
- Vol. 7 (3) , 210-222
- https://doi.org/10.1101/gr.7.3.210
Abstract
A YAC/STS map of the X chromosome has reached an inter-STS resolution of 75 kb. The map density is sufficient to provide YACs or other large-insert clones that are cross-validated as sequencing substrates across the chromosome. Marker density also permits estimates of regional gene content and a detailed comparison of genetic and physical map distances. Five regions are detected with relatively high G + C, correlated with gene richness; and a 17-Mb region with very low recombination is revealed between the Xq13.3 [XIST] and Xq21.3 XY homology loci.Keywords
This publication has 43 references indexed in Scilit:
- A synaptobrevin–like gene in the Xq28 pseudoautosomal region undergoes X inactivationNature Genetics, 1996
- A 2-Megabase Physical Contig Incorporating 43 DNA Markers on the Human X Chromosome at p11.23–p11.22 from ZNF21 to DXS255Genomics, 1996
- Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD lociHuman Molecular Genetics, 1996
- A comprehensive genetic map of the human genome based on 5,264 microsatellitesNature, 1996
- A bidirectional YAC walk from the Norrie disease (NDP) locusGenomics, 1995
- A 6-Mb YAC contig in Xp22.1–p22.2 spanning the DXS69E, XE59, GLRA2, PIGA, GRPR, CALB3, and PHKA2 genesGenomics, 1995
- The isochore organization of the human genome and its evolutionary history — a reviewGene, 1993
- Construction of a 2.6-Mb contig in yeast artificial chromosomes spanning the human dystrophin gene using an STS-based approachGenomics, 1992
- Construction and characterization of a yeast artificial chromosome library containing seven haploid human genome equivalents.Proceedings of the National Academy of Sciences, 1990
- Cloning of Large Segments of Exogenous DNA into Yeast by Means of Artificial Chromosome VectorsScience, 1987