Cardiovascular Effect of Oxytocin in Rodents and a Marsupial.

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Abstract
Summary The effects of oxytocm on arterial pressure and regional circulation were studied in rats, guinea pigs, rabbits and opossums. It was found that oxytocin increased arterial pressure in all species of animals studied. The magnitude of the increase in pressure was essentially in proportion to the doses given, but was greater in opossums than in 3 rodents studied. Oxytocin always increased arterial pressure more markedly in reserpinized rats than in control rats. However, the maximal pressure attained following equivalent doses of oxytocin was always lower in reserpinized rats than in control rats. The i.a. injection of oxytocin was found to increase the peripheral vascular resistance in rabbits, indicating the vasoconstricting effect of the drug.

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