Electrophilic substitution in five-membered heterocyclic systems. Part VI. Kinetics of the bromination of the 2-methoxycarbonyl derivatives of furan, thiophen, and pyrrole in acetic acid solution
- 1 January 1968
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society B: Physical Organic
- p. 392-394
- https://doi.org/10.1039/j29680000392
Abstract
The kinetics of bromination of the 2-methoxycarbonyl derivatives of thiophen, furan, and pyrrole in acetic acid in the presence of an excess of bromide ions exhibit the same characteristic features as those of the bromination of benzene derivatives. The relative rates for bromination at the α-position are : 2-methoxycarbonylthiophen 1, 2-methoxycarbonylfuran 1·2 × 102, and 2-methoxycarbonylpyrrole 5·9 × 108.Keywords
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