Opioid hyperexcitability: the application of alternate opioid therapy
- 1 June 1993
- journal article
- case report
- Published by Wolters Kluwer Health in Pain
- Vol. 53 (3) , 353-355
- https://doi.org/10.1016/0304-3959(93)90232-e
Abstract
Three cases are reported where patients experienced severe central nervous system adverse effects on high-dose hydromorphone. These effects were rapidly alleviated following a change in therapy to morphine at 20-25% of the usually accepted potency equivalent dose. We recommend caution in using equivalent dose tables when changing opioid therapy in patients receiving high-dose opioid treatment.Keywords
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