Interferon Assay of High Sensitivity

Abstract
A method of aging cells is described which allows for an increase in sensitivity of the interferon assay. After reaching confluency the cell cultures are aged at 30.degree. C for 5 days, the growth medium is replenished, and the cells are incubated for an additional 24 h at 37.degree. C before applying interferon. Using cell cultures so treated ([human] diploid [fibroblast] cells HFS-1 or HR-203), and mouse [fibroblast] L-929 cells), the sensitivity of the interferon assay increase from 16- to 30-fold for human and up to 10-fold for mouse standard interferon.

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