Interaction in the cerebral metabolism of the biogenic amines: Effect of intravenous infusion of l‐tryptophan on tryptophan and tyrosine in brain and body fluids

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Abstract
1 The distribution of the amino-acids tryptophan and tyrosine has been determined in plasma ultrafiltrate, whole plasma, erythrocytes, cerebrospinal fluid (c.s.f.) and various regions of the brain in dogs. 2 The effect of tryptophan administration on the distribution of both these amino-acids showed that the alterations produced in tryptophan concentration did not appear to change the concentrations of tyrosine from their normal pattern. 3 The implications of these results with regard to amino-acid transport systems in man and dog are discussed.

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