THE EFFECTS OF TESTOSTERONE PROPIONATE ON RENAL FUNCTION IN THE DOG, AS MEASURED BY THE CREATININE AND DIODRAST CLEARANCE AND DIODRAST TM

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Abstract
The effect of testosterone on renal function in 3 [female] dogs was measured by means of the clearances of creatinine and diodrast and by the diodrast Tm. 100 mgs. of testosterone propionate in sesame oil was given daily by subcut. inj. The glomerular filtration rate (creatinine clearance) and effective renal blood flow (diodrast clearance) were not significantly affected. The ability of the tubules to excrete iodine (diodrast Tm) was increased markedly. In 2 of 3 animals the diodrast Tm rose to double the control value. In 1 dog the daily urinary excretion of Na and K was followed during a control period and during the period of testosterone adm. The excretion of both Na and K was decreased during the period of therapy when the diodrast Tm was increased. The increase in diodrast Tm was reversible, although the length of time required for it to return to normal varied widely. The relationship of the observed changes in diodrast Tm to renal function and morphology is discussed.