THE EFFECT OF MICELLAR SOLUBILIZATION ON MUCOSAL METABOLISM OF ABSORBED GLYCERYL‐1‐MONOETHER

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Abstract
Summary: A lipid mixture containing labelled oleic acid and labelled glycerol‐1‐monoether was infused intraduodenally at a steady rate for 6 hours in unanaesthetized rats with biliary and thoracic duct lymph fistulae. There were three groups, each of which received the same lipid mixture and dose but in dillerent physical states: micellar in bile salts 10 mM, micellar in non‐ionic detergent (Pluronic F68) and as a fine emulsion in bile salts 1 mM with no micellar phase. When a steady state of absorption had been reached the absorption rate relative to area of small intestine utilized was greatest for micellar bile salt infusate and least for non‐micellar emulsion, with intermediate values for non‐ionic micellar solution. There were differences in distribution of absorbed monoether label in the mucosa which suggested that metabolism of this model compound was affected by the rate of absorption. The percentage of monoether label which was saponifiable, i.e. which had been hydrolyzed and oxidized to fatty acid, was greater the more slowly the lipid was absorbed. On the other hand, the proportion of unsplit monoether label which was esterified was smaller the more slowly the lipid was absorbed. Since the results for non‐ionic micellar infusate, containing no bile salts, fell between those for high and low concentrations of bile salts, it seemed that metabolism of monoetber was affected more by the absorptive flux rate than by a metabolic effect of bile salts, per se.

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