Cerebrospinal Fluid Dynamics and Hydrocephalus after Experimental Subarachnoid Hemorrhage

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Abstract
The effects of three sequential injections of cisternal blood on ventricular size, cerebrospinal fluid (CSF) pressure, CSF formation rate, and CSF absorption rate were evaluated in adult rabbits. Autologous blood was injected into the cisterna magna on Days 1, 4, and 8 and ventriculocisternal perfusion was done on Day 15. Control animals received artificial CSF injection at these intervals. For each rabbit, the mean CSF pressure was higher after three injections of blood than before; 13 animals after blood injection had a mean CSF pressure of 15.59 ± 1.15 cm H2O (mean ± SE); before blood injection, their pressure had been 11.14 ± 1.43 cm H2O (all figures are means ± SE). This is a significant increase in pressure (PP<0.01, two-tailed t-test). CSF formation and absorption rates were not significantly different after subarachnoid hemorrhage. The CSF formation rates were 9.85 ± 1.8 μ1/minute in the experimental group and 9.53 ± 1.9 μ1/minute in the control group; CSF absorption at the animal's opening pressure was 13.30 ± 2.06 μ1/minute in the animals with cisternal blood injection and 9.97 ± 2.4 μ1/minute in the control animals. Seven of 8 animals tested after blood injection had a pressure differential between ventricle and cistern, suggesting that relative aqueductal stenosis may play a part in the development of hydrocephalus after experimental subarachnoid hemorrhage.

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