Incorporation of C14 of Acetate-1-C14 and Pyruvate-2-C14 into Brain Cholesterol in the Intact Rat

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Abstract
In-corporation of C14 into brain cholesterol following the intracisternal injection of labeled acetate and pyruvate was observed in both young and adult rats. At six hours after the injection of labeled acetate, the per cent of the injected dose found in extracted brain cholesterol varied from 0.013 for 1-year-old rats to 0.170 for weanling rats. With pyruvate the incorporation was less than with acetate. Unlabeled acetate inhibited the incorporation of the C14 of labeled pyruvate. The labeled brain cholesterol failed to show a measurable decline in activity during a 72-day period.

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