AMINO ACID DECARBOXYLASES OF PROTEUS MORGANII. II. SIMULTANEOUS FORMATION OF TWO INDUCED ENZYMES BY A SINGLE INDUCER

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Abstract
L-Histidine(His) induced the adaptive formation of His-decarboxylase alone, L-ornithine(Orn) His-and Orn-decarboxylases, and L-glutamic acid (Glu) Or-, and Glu-decarboxylases. No adaptive enzymes were formed to metabolize histamine, putrescine or gamma-aminobutyric acid in any cases. L-Aspartic acid (Asp) induced Glu-decarboxylase, whereby Asp presumably gave a rise to an inducer, Glu by transaminase activity of the cells, while His did not produce Glu-decarboxylase inspite of the presence of His-alpha-ketoglutarate transaminase activity. A most likely interpretation is the "cross reaction", by which an inducer causes the adaptive formation of not only its own enzyme but also of a few other enzymes corresponding to the substrates closely related to the added inducer.