Effects of Selected Ginsenosides on Phorbol Ester‐Induced Expression of Cyclooxygenase‐2 and Activation of NF‐κB and ERK1/2 in Mouse Skin
- 1 November 2002
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 973 (1) , 396-401
- https://doi.org/10.1111/j.1749-6632.2002.tb04672.x
Abstract
Our previous studies have demonstrated that the methanol extract of heat-processed Panax ginseng C.A. Meyer exerts antioxidative, antiinflammatory, and anti-tumor-promoting effects. In the present study, we examined the antiinflammatory effects of several ginsenosides (Rb(1), Rc, Re, Rg(1), Rg(3)) derived from P. ginseng. Topical application of each of these ginsenosides significantly attenuated ear edema induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). These ginsenosides also suppressed expression of cyclooxygenase-2 (COX-2) and activation of NF-kappaB in the TPA-treated dorsal skin of mice. Of the ginsenosides tested, Rg(3) was found to be most effective in terms of inhibiting TPA-induced ear edema, COX-2 expression, and NF-kappaB activation.Keywords
This publication has 9 references indexed in Scilit:
- Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-κB activation and tumor promotionMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2003
- Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activationPublished by Elsevier ,2001
- Steaming of Ginseng at High Temperature Enhances Biological ActivityJournal of Natural Products, 2000
- Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginsengPublished by Elsevier ,2000
- Ginseng pharmacologyBiochemical Pharmacology, 1999
- Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substancesMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1999
- Extracellular-Regulated Kinase 1/2, Jun N-Terminal Kinase, and c-Jun Are Involved in NF-κB-Dependent IL-6 Expression in Human MonocytesThe Journal of Immunology, 1999
- Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharideBiochemical Pharmacology, 1997
- Cancer‐Protective Factors in Fruits and Vegetables: Biochemical and Biological Background.Basic & Clinical Pharmacology & Toxicology, 1993