Action of Erythromycin on "Protoplasts" in vivo
- 4 December 1964
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 146 (3649) , 1299-1300
- https://doi.org/10.1126/science.146.3649.1299
Abstract
Bacteria may persist in "protoplast" form in kidneys after treatment of experimental enterococcal pyelonephritis with penicillin. Erythromycin, while ineffective against the bacterial form of infection, was able to kill "protoplasts" in vivo. This finding is consistent with the hypothesis that intact cell wall interferes with the ingress of erythromycin into the cellular area in which it acts.Keywords
This publication has 3 references indexed in Scilit:
- Erythromycin: Mode of ActionScience, 1964
- Persistence of Bacteria in "Protoplast" Form after Apparent Cure of Pyelonephritis in RatsScience, 1964
- Similarity in mode of action of chloramphenicol and erythromycinBiochimica et Biophysica Acta, 1959