Absence of cholinergic deficits in “pure” vascular dementia
- 11 January 2005
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 64 (1) , 132-133
- https://doi.org/10.1212/01.wnl.0000148591.63727.80
Abstract
Choline acetyltransferase in temporal cortex was evaluated as a marker of cholinergic function in autopsied dementia cases (9 vascular dementia [VaD] cases, 12 “mixed” VaD and Alzheimer disease [AD] cases, 10 AD cases, 12 control subjects). Patients with AD (t = 2.5, p = 0.02) and “mixed” VaD and AD (t = 3.8, p = 0.001) had greater cholinergic deficits than age-matched control subjects and patients with “pure” VaD. The absence of cholinergic deficits in “pure” VaD may be relevant to the pharmacologic treatment of these patients.Keywords
This publication has 9 references indexed in Scilit:
- Cholinergic denervation in a pure multi-infarct stateNeurology, 2003
- Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trialPublished by Elsevier ,2002
- Galantamine for vascular dementia: some answers, some questions.The Lancet, 2002
- Neuropathological Substrates of Dementia and Depression in Vascular Dementia, with a Particular Focus on Cases with Small Infarct VolumesDementia and Geriatric Cognitive Disorders, 2000
- Cerebral infarcts in patients with autopsy-proven Alzheimer's diseaseNeurology, 1998
- Brain Infarction and the Clinical Expression of Alzheimer DiseaseThe Nun StudyJAMA, 1997
- Vascular dementiaNeurology, 1993
- Senile dementia of Lewy body typeJournal of the Neurological Sciences, 1990
- Neurotransmitter enzyme abnormalities in senile dementiaJournal of the Neurological Sciences, 1977