Three-dimensional Huh7 cell culture system for the study of Hepatitis C virus infection
Open Access
- 15 July 2009
- journal article
- Published by Springer Nature in Virology Journal
- Vol. 6 (1) , 103
- https://doi.org/10.1186/1743-422x-6-103
Abstract
In order to elucidate how Hepatitis C Virus (HCV) interacts with polarized hepatocytes in vivo and how HCV-induced alterations in cellular function contribute to HCV-associated liver disease, a more physiologically relevant hepatocyte culture model is needed. As such, NASA-engineered three-dimensional (3-D) rotating wall vessel (RWV) bioreactors were used in effort to promote differentiation of HCV-permissive Huh7 hepatoma cells.Keywords
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