NEUROLOGICAL AND INTELLECTUAL SEQUELAE OF REYE SYNDROME

1 January 1978

journal article
research article

Vol. 82 (6) , 535-541

Abstract

Survivors (11) of Reye''s syndrome (aged 9 mo.-12 yr) were evaluated for neurological and psychoeducational sequelae; 7 children showed significant neuropsychological sequelae. These ranged from severe global psychomotor retardation to mild specific perceptual and/or language impairments and from spastic quadriplegia and decorticate posturing to mild dysarthria. The severity of sequelae was inversely related to age of the child at onset of the disease. Those children developing the syndrome when they were less than 1 yr of age were seriously impaired while 3 children developing it in late childhood sustained no sequelae. Biochemical and neurological status at disease onset did not predict neuropsychological outcome. The pattern of sequelae paralleled that of other encephalopathies and suggested the importance for both child and family of early developmental evaluation following recovery from the disease.

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