Stereochemical control of the interfacial darzens condensation
- 1 January 1977
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 24,p. 902-903
- https://doi.org/10.1039/c39770000902
Abstract
The condensation of α-chlorophenylacetonitrile (1) with benzaldehyde (2) carried out in the presence of 50% aq. NaOH and a quaternary ammonium catalyst gives trans-2,3-diphenylglycidonitrile, while without the catalyst, the cis-isomer predominates; in the latter case the reaction proceeds at the interface.Keywords
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