Atropisomer-selective 1,1-binapthyl synthesis via chirality transfer from sulfur
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 19,p. 1489-1491
- https://doi.org/10.1039/c39930001489
Abstract
4,5-Dihydro-2-(1-alkyl- or 1-aryl-sulfinylnaphthalen-2-yl)-4,4-dimethyloxazoles 3–6 undergo substitution reactions on treatment with Grignard reagents; the optically active sulfoxide 14 on treatment with 1-naphthylmagnesium bromide furnished the 1,1-binaphthyl 15 in 60% enantiomeric excess (e.e.).Keywords
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